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Holistic integrative medicine: toward a new era of medical advancement

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《医学前沿（英文）》 2017年第11卷第1期页码 152-159 doi: 10.1007/s11684-017-0499-6

摘要：

Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine (HIM), which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.

关键词： holistic integrative medicine precision medicine general practice medicine

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新形势下中西医结合医学的发展思考

王聪慧,冯哲,尹智炜,李爽,陈香美

《中国工程科学》 2021年第23卷第2期页码 169-174 doi: 10.15302/J-SSCAE-2021.02.016

摘要：

新型冠状病毒肺炎（ COVID-19）疫情席卷全球，中西医结合医学作为我国特有的医学模式，在抗击疫情过程中发挥了重要作用；及时总结运用经验，提升中西医结合医学事业发展水平，将为我国全民健康与医药卫生事业发展提供坚实保障。本文利用文献分析、问卷调查等方法获得的基础数据，梳理了新中国成立以来中西医结合取得的基础成绩，总结了中西医结合医学在 COVID-19 疫情防控方面发挥的关键作用；在梳理发展现状的基础上，研判了中西医结合在医疗资源、临床教育科研、国际化等方面存在的不足。研究提出了实现中西医结合继承创新、引领世界传统医药与现代医学结合发展等我国新形势下中西医结合医学的建设目标；据此建议，完善中西医结合治理体系，加强中西医结合防治人才和队伍建设，积极推动中西医结合国际交流发展，弘扬中西医结合文化。

关键词：中西医结合医学循证医学评价体系人才培养新型冠状病毒肺炎

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A holistic approach for evaluating ecological water allocation in the Yellow River Basin of China

YANG Zhifeng, CUI Baoshan, CHEN He

《环境科学与工程前沿（英文）》 2007年第1卷第1期页码 99-106 doi: 10.1007/s11783-007-0019-z

摘要： The characteristics and sustainable management of water resources on a basin scale require that they should be managed using a holistic approach. In this study, a holistic methodology called the holistic approach in a basin scale (HABS) is proposed to determine the ecological water requirements of a whole basin. There are three principles in HABS. First, ecological water requirements in a basin scale indicate not only the coupling of hydrological and ecological systems, but also the exchange of matter and energy between each ecological type through all kinds of physical geography processes. Second, ecological water requirements can be divided into different types according to their functions, and water requirements of different types are compatible. Third, ecological water requirements are related to a multiple system including water quality, water quantity, and time and space, which interact with each other. The holistic approach in a basin scale was then used in the Yellow River Basin and it suggested that 265.0 × 10 m of water, 45% of the total surface water resources, should be allocated to ecological systems, such as rivers, lakes, wetlands and cities, to sustain its function and health. The ecological water requirements of inside river systems and outside river systems were respectively 261.0 × 10 and 3.65 × 10 m.

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

《农业科学与工程前沿（英文）》 2022年第9卷第3期页码 316-332 doi: 10.15302/J-FASE-2022441

摘要：

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

关键词： Nitrogen root system architecture phytohormone crosstalk nitrogen-use efficiency breeding strategy

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整合药学发展的战略思考

张勇,赵一秀,杨宝峰

《中国工程科学》 2021年第23卷第1期页码 185-192 doi: 10.15302/J-SSCAE-2021.01.022

摘要：

整合药学是以现代药学为基础、随着人类对复杂性疾病认识的日益深刻而提出来的，涉及新药研发、传统医药创新、临床药学实践、药学学科建设及人才培养等诸多领域。为推进我国整合药学实践的发展，本文运用文献研究、学术交流、专家咨询等方法，阐明了整合药学理念及内涵，提出了整合药学的未来发展战略。研究指出，要促进现代药学与传统药学的整合，应建立健全整合用药临床实践指南、鼓励基于整合思维的创新中药研究、规范整合中西药临床应用；推进基于整合药学的新药研发，应创新整合药物设计思路、开发适应整合药学的药物评价体系、加快建设整合药物的新药研发体系；推进整合药学的临床实践，应进一步完善以患者为中心的临床用药指导、实现个体化治疗、丰富整合药学临床实践内容、加强整合药物合理应用；推进整合药学学科建设，应丰富基于整合药学的药学本科理论和实践课程、加强教育培训及专业间协作。整合药学是现代药学理论和实践的变革与发展，融合药学各相关学科的理论与实践，是构建促进人类健康、完善医疗体系的新型药学理论和实践体系。

关键词：整合药学，整合药物，新药研发，药物评价，临床用药指导

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A NEW APPROACH TO HOLISTIC NITROGEN MANAGEMENT IN CHINA

《农业科学与工程前沿（英文）》 2022年第9卷第3期页码 490-510 doi: 10.15302/J-FASE-2022453

摘要：

● Progress on nitrogen management in agriculture is overviewed in China.

关键词： 4R technology food chain N management N use efficiency soil-crop system sustainable management

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

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《医学前沿（英文）》 2012年第6卷第1期页码 1-7 doi: 10.1007/s11684-012-0173-y

摘要：

The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.

关键词： individualized medicine health medicine constitutional theory in Chinese medicine

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

《医学前沿（英文）》 2011年第5卷第2期页码 163-170 doi: 10.1007/s11684-011-0143-9

摘要： The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice, but without the benefit of undergoing the experimental medicine stage. Although Chinese medicine has formed a systematic and unique theory system through thousands of years, with the development of evidence-based medicine, the bondage of the research methods of experience medicine to Chinese medicine is appearing. The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine. According to the features of Chinese medicine, we propose the research idea of “taking two ways simultaneously,” which is the study both in the ideal condition and in the real world. Analyzing and constructing the theoretical basis and methodology of clinical research in the real world, and building the stage for research technique is key to the effective clinical research of Chinese medicine. Only by gradually maturing and completing the clinical research methods of the real world could we realize “taking two ways simultaneously” and complementing each other, continuously produce scientific and reliable evidence of Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

关键词： Chinese medicine experience medicine evidence-based medicine real world

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Clinical research of traditional Chinese medicine in big data era

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《医学前沿（英文）》 2014年第8卷第3期页码 321-327 doi: 10.1007/s11684-014-0370-y

摘要：

With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.

关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine

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光照世界史坛的中医起源之谜

符友丰

《中国工程科学》 2006年第8卷第9期页码 1-12

摘要：

以疫病流行及其原型分析为线索，联系早期治法（如热熨、火灸、砭刺等）探讨了古代以腺鼠疫为代表的疫病流行与医学起源间的内在联系；以医源于疫的视野分析我国医史病史研究在出土文物、古文字和医学文献等方面丰富的信息资源与优势；分析解读疾病名实的古今变迁、比较中西医学及其在认识论与方法论上的差异，为审视我国传统医学在疫病防治方面的丰富经验与延至今日的独到成就与意义，疾病史研究成果与推广，实现古为今用，将为当今疫病防治的中西互补、中西医结合与比较提供宝贵的历史经验与借鉴。

关键词：世界医学史中医史医学起源鼠疫霍乱天花比较医学

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

《医学前沿（英文）》 2011年第5卷第2期页码 123-126 doi: 10.1007/s11684-011-0124-z

摘要： Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency syndrome (AIDS) in China in recent years. In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIV/AIDS) treatment with TCM. The use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment side effects, and improving the quality of life. The potential beneficial effects of TCM should be confirmed through extensive and rigorous trials.

关键词： HIV/AIDS traditional Chinese medicine

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Traditional Chinese medicine in the new century

Jianxiang Liu, Zhu Chen

《医学前沿（英文）》 2011年第5卷第2期页码 111-114 doi: 10.1007/s11684-011-0125-y

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Do not let precision medicine be kidnapped

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《医学前沿（英文）》 2015年第9卷第4期页码 512-513 doi: 10.1007/s11684-015-0425-8

摘要：

Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

关键词： precision medicine personalized medicine genomics

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Employing electricity-consumption monitoring systems and integrative time-series analysis models: A case

Seiya MAKI, Shuichi ASHINA, Minoru FUJII, Tsuyoshi FUJITA, Norio YABE, Kenji UCHIDA, Gito GINTING, Rizaldi BOER, Remi CHANDRAN

《能源前沿（英文）》 2018年第12卷第3期页码 426-439 doi: 10.1007/s11708-018-0560-4

摘要：

The Paris Agreement calls for maintaining a global temperature less than 2°C above the pre-industrial level and pursuing efforts to limit the temperature increase even further to 1.5°C. To realize this objective and promote a low-carbon society, and because energy production and use is the largest source of global greenhouse-gas (GHG) emissions, it is important to efficiently manage energy demand and supply systems. This, in turn, requires theoretical and practical research and innovation in smart energy monitoring technologies, the identification of appropriate methods for detailed time-series analysis, and the application of these technologies at urban and national scales. Further, because developing countries contribute increasing shares of domestic energy consumption, it is important to consider the application of such innovations in these areas. Motivated by the mandates set out in global agreements on climate change and low-carbon societies, this paper focuses on the development of a smart energy monitoring system (SEMS) and its deployment in households and public and commercial sectors in Bogor, Indonesia. An electricity demand prediction model is developed for each device using the Auto-Regression eXogenous model. The real-time SEMS data and time-series clustering to explore similarities in electricity consumption patterns between monitored units, such as residential, public, and commercial buildings, in Bogor is, then, used. These clusters are evaluated using peak demand and Ramadan term characteristics. The resulting energy-prediction models can be used for low-carbon planning.

关键词： electricity monitoring electricity demand prediction multiple-variable time-series modeling time-series cluster analysis Indonesia

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中医的渊源和对中医学发展的思考

王文奎,王峰,王岭

《中国工程科学》 2006年第8卷第4期页码 1-11

摘要：

传统的中医学源远流长，博大精深，疗效显著，由于种种历史原因，加之自身流派众多，传承艰难，流传至今，已不能满足现代社会的发展与要求。中医要发展，须走“医学衷中纳西”的与时俱进之路。中医自身要统一理论认识，统一辩证纲领，统一到“五脏阴阳”之中，以“三维守恒”指导辩证，要明确医学的目的，认识生命的本质和生命运动的机制；要宏观与微观相结合，整体与局部相统一，以唯象涵盖唯物，以辩证指导分析，以调为本，以平为期；要司岁备药，先法制病，对中药剂型进行改进，以适应社会发展的需要。

关键词：中医发展历程与现状衷中纳西中药剂型